Hyperkalemia causes progressive electrocardiographic changes that reflect the impact of increased potassium on the membrane potential of cardiac cells. It is defined as a serum potassium level > 5.0 mEq/L.

ECG Changes

  • High-amplitude, symmetric, narrow-based T wave, producing a peaked appearance (“tented” T wave)
  • Progressive decrease of the P wave associated with progressive lengthening of the PR interval
  • Increased QRS duration
  • Sine-wave rhythm preceding malignant arrhythmias such as ventricular fibrillation and asystole

ECG in Hyperkalemia

Electrocardiogram showing hyperkalemia

Hyperkalemia. Note the high-amplitude, symmetric T waves.

Electrocardiogram showing hyperkalemia

Hyperkalemia. ECG with signs of LVH and peaked T waves in a patient with chronic kidney disease.

Electrocardiogram showing hyperkalemia

Hyperkalemia. In this example, in addition to peaked T waves, we see flattening of the P wave and increased QRS duration.

Classic ECG Changes in Hyperkalemia

ECG manifestations vary according to the serum potassium level:

  • 5.5 – 6.5 mEq/L: tall, symmetric, narrow-based T wave (“tented” appearance).
  • 6.5 – 7.0 mEq/L: reduced P-wave amplitude and progressive lengthening of the PR interval.
  • 7.0 – 9.0 mEq/L: progressive widening of the QRS complex, possibly with ST-segment changes.
  • > 9.0 mEq/L: sine-wave pattern on the ECG, associated with a high risk of ventricular fibrillation (VF) and asystole.
ECG changes in hyperkalemia
ECG changes in hyperkalemia

Further Reading

References

  1. Scheffer MK, De Marchi MFN, de Alencar Neto JN, Felicioni SP. Eletrocardiograma de A a Z. São Paulo: Manole, 2024.
  2. de Alencar JN, de Andrade Matos VF, Scheffer MK, Felicioni SP, et al. ST segment and T wave abnormalities: A narrative review. J Electrocardiol. 2024;85(500):7–15.